Copper Peptide-1 CAS 49557-75-7

Blue copper peptide, also known as copper peptide or GHK-Cu, is a complex formed by GHK (tripeptide -1) and copper ions, and its essence is a fragment of human type I collagen. Discovered by Dr. Lauren Pickart in 1973, this component is high in the blood of young people and has important physiological activities such as promoting wound repair and activating tissue remodeling. The follow-up research further shows that blue copper peptide can promote the synthesis of collagen, elastin and other substrates, accelerate tissue repair, and has many biological activities such as anti-inflammatory and anti-oxidation.

As we know, peptide raw materials are small molecular protein composed of amino acids linked by peptide bonds, which can be divided into dipeptide and tripeptide according to the number of amino acids. In the process of natural skin aging, peptides are involved in many physiological processes such as cell proliferation, inflammatory reaction, pigment formation and protein synthesis. In the field of cosmetics, peptides API powder are widely used to promote collagen production, anti-aging, repair and whitening.
Copper Peptide-1 is one of the earliest and most widely used cosmetic peptides. Since its discovery, its wound healing function was confirmed in 1985, and its role as tissue remodeling activator and signal peptide was further recognized in 1999, which can promote the degradation of scar tissue, stimulate the synthesis of normal collagen, elastin and proteoglycan, regulate cell growth and migration, and play an anti-inflammatory and antioxidant role.

What are the functions and benefits of blue copper peptide-1?

copper peptide -1, also known as tri-peptide (copper peptide), is formed by three amino acids, namely glycyl -L- histidyl -L- lysine. These three amino acids are ternary molecules connected by two peptide bonds, and this structure can effectively prevent the nerve conduction of a choline substance harmful to the skin, relax muscles and improve dynamic wrinkles. According to the relevant clinical verification data, COPPER TRIPEPTIDE-1 has the functions of anti-carbonylation, protecting collagen from being damaged by activated carbon groups, promoting the growth of type III collagen, antioxidation and anti-saccharification.However, the current discussion is that copper ions participate in the whole skin healing mechanism, that is, repair and anti-aging effects.In addition, some scientific and technological articles in this field indicate that it can also release signals, induce fibroblasts to produce collagen, promote collagen production, and stimulate the synthesis of glucose polyamines (GAGs), so as to enhance skin elasticity, improve facial texture, play a anti-aging role, and is mild and non irritating. It is currently the most ideal anti-aging ingredient that is friendly to skin sensitive people.

What is the testing method for Copper Peptide-1?

Copper Peptide-1 is a ternary molecule composed of three amino acids connected by two peptide bonds, but it still belongs to degraded small molecule collagen. Its detection method still follows the detection logic of oligopeptide chains. In clinical applications, liquid chromatography (HPLC) is the most commonly used and critical detection method for peptide analysis. the right figure, the ChromCore AQ C18 chromatographic column and other brands of Competitor A C18 chromatographic columns were used for nano spectrum analysis. The substance was tested under water/acetonitrile solution, and the test spectrum is as follows:
ChromCore AQ C18 column for nano-spectral analysis benefits from excellent particle size distribution, and has a higher theoretical plate number than other brands of Competitor A C18 columns.

Does blue Copper Peptide-1 have any side effects on the skin?

The effect on the skin is to replenish water, moisturize and whiten, because it can effectively lock in 30 times of water, make the skin moist and tender for a long time, and in addition, it can achieve whitening effect by inhibiting the production process of melanin. Secondly, it can repair the broken and aging elastic fiber web, which can restore the elasticity of skin, delay aging and remove free radicals in the body.

blue copper peptide-1 has a good effect on wound healing and skin reconstruction, which can reduce scar tissue formation, stimulate skin to heal itself and restore skin elasticity.

1, improve the repair ability. Blue copper peptide can improve the self-repair ability of skin, it can promote the synthesis of skin matrix, strengthen the regeneration ability of cells, so that when the skin is damaged, it can heal and recover faster, and let normal cell tissue replace the old one.

2. Promote absorption. The molecular structure of blue copper peptide is very small, and most of them are small molecular proteins with amino acids, which are very easy to absorb. Adding it to cosmetics can promote the absorption of other ingredients. If the skin's absorption ability is not strong, this effect will become more and more obvious.

3. Deep skin rejuvenation. When the blue copper peptide penetrates into the bottom layer of the skin, it can stimulate the vitality of cells, enhance the activity of the skin, make the skin moist and elastic, give off a more luster and moist feeling from the inside out, and enhance the skin's own functions to a certain extent.

As for whether there are side effects, no favorable proof has been found in the current experiment, because it has been used in human tissue repair for a long time, and there is no evidence of weak correlation, so we can guarantee that it is safe and reliable.

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Q1: What is its recommended concentration? ​
0.1%-0.5% concentration is recommended for healthy skin to maintain stability and resist aging, 1% concentration can be used for accelerated repair of damaged skin, and 0.5%-1% for soothing repair of sensitive muscles. It is necessary to establish tolerance from low concentration and gradually increase the frequency of use.
Q2: Can it be used every day? ​
It can be used every day, but it is not recommended to use it continuously for a long time to avoid skin adaptability. Sensitive muscles are recommended to be used every other night, and the frequency should be adjusted according to the skin condition.
Q3: What ingredients can't it match? ​
copper peptide-1 powder<5), so it should be avoided to use it together with the following components:

Acids: fruit acid, salicylic acid, tretinoin and its derivatives.
Strong antioxidant: high concentration of vitamin C (prototype VC).
Certain chelating agents.
Others: nicotinamide (high concentration), Asiatic acid, etc.
Q4: If these ingredients must be used, how should they be matched? ​
It is suggested to adopt the strategy of "morning and evening sharing" or "time interval" to ensure full absorption.
Q5: Can it repair red blood? ​
It can thicken the stratum corneum and reduce the content of red blood silk, which has certain effect on improving red blood silk, but it needs long-term use. For the serious problem of red blood silk, it is suggested to combine laser treatment and other medical and aesthetic means.
Q6: Can I use it after medical beauty? ​
Sure. Blue copper peptide is a gold restoration component after medical beauty projects such as laser and microneedle, which can greatly shorten the recovery period and reduce the risk of color deposition. But avoid the wound area and use it under the guidance of a doctor.
Q7: Is it effective for acne muscles? ​
It has anti-inflammatory effect, can inhibit the release of inflammatory factors, and has a certain effect on improving inflammatory skin problems such as acne and acne. At the same time, it can promote wound healing and reduce acne marks.

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